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Related Experiment Video

Updated: May 13, 2026

Manganese Oxide Nanoparticle Synthesis by Thermal Decomposition of Manganese(II) Acetylacetonate

Manganese Oxide Nanoparticle Synthesis by Thermal Decomposition of Manganese(II) Acetylacetonate

Published on: June 18, 2020

Redox-activated manganese-based MR contrast agent.

Galen S Loving¹, Shreya Mukherjee, Peter Caravan

¹A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Suite 2301, Charlestown, Massachusetts 02129, USA.

Journal of the American Chemical Society

|March 21, 2013

Summary

This summary is machine-generated.

This study introduces a manganese (Mn) coordination complex as a novel redox-sensitive magnetic resonance (MR) imaging probe. It demonstrates a significant MR signal change in response to glutathione and hydrogen peroxide.

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Area of Science:

Biomedical Imaging
Inorganic Chemistry
Materials Science

Background:

Magnetic resonance (MR) imaging is a crucial diagnostic tool.
Developing sensitive and responsive contrast agents is essential for advanced MR imaging.
Manganese (Mn) complexes offer potential as MR contrast agents due to their paramagnetic properties.

Purpose of the Study:

To develop a novel redox-sensitive manganese-based magnetic resonance (MR) imaging probe.
To investigate the utility of a specific Mn coordination complex with an HBET ligand for detecting biological redox changes.
To characterize the relaxivity changes of the Mn complex under different redox conditions.

Main Methods:

Synthesis and characterization of a manganese-HBET coordination complex.
Evaluation of the complex's stability across Mn(2+) and Mn(3+) oxidation states.
Assessment of relaxivity changes in the presence of glutathione (GSH) and hydrogen peroxide (H2O2).
MR signal measurements to quantify changes induced by redox agents.

Main Results:

The HBET ligand effectively stabilizes both Mn(2+) and Mn(3+) oxidation states.
In the presence of glutathione (GSH), Mn(III)-HBET is converted to Mn(II)-HBET, resulting in a 3-fold increase in relaxivity and MR signal.
Hydrogen peroxide (H2O2) converts Mn(II)-HBET back to Mn(III)-HBET, leading to a decrease in MR signal.

Conclusions:

The developed Mn-HBET complex functions as a sensitive redox-sensitive MR probe.
The probe exhibits distinct MR signal changes in response to biologically relevant redox species like GSH and H2O2.
This Mn coordination complex holds promise for advanced redox-sensitive MR imaging applications.