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Updated: May 13, 2026

Characteristics of Precipitation-formed Polyethylene Glycol Microgels Are Controlled by Molecular Weight of Reactants
Published on: December 23, 2013
More on polypseudorotaxanes formed between poly(ethylene glycol) and α-cyclodextrin
Edvaldo Sabadini1, Fernanda do Carmo Egídio, Terence Cosgrove
1Department of Physical-Chemistry, Institute of Chemistry, University of Campinas UNICAMP, Campinas, SP, Brazil. sabadini@iqm.unicamp.br
Abstract:
A new interpretation for the mechanism associated with the spontaneous threading of α-CD, onto a PEG chain followed by the supramolecular hydrogel formation, is described. Beyond a specific stoichiometry, the complexation of α-CD and PEG results in the formation of a two-phase system. Besides the phase separation, for PEG with a molecular weight higher than 6000 Da, part of the polymer chains are unthreaded by the α-CD, leading to the formation of a supramolecular hydrogel. The kinetics for the complexation and the determination of the yield for equilibrated systems consisting of PEG (linear and star) are used to investigate the number of α-CD threaded before and after the phase separation. The results are compared with the prediction obtained from the application of the Poisson distribution and reveal the ratio between α-CD and PEG in each step of the process. Additionally, the kinetics for the hydrogel formation and its inner structure are investigated by using the proton NMR spin-spin relaxation of water.
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