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Related Experiment Video

Updated: May 13, 2026

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
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Working memory in recurrent brief depression: an fMRI pilot study.

Maria Stylianou Korsnes1, Hans Lövdahl, Stein Andersson

  • 1Department of Psychiatry of Old Age, Oslo University Hospital, Ullevaal, Norway. markor@ous-hf.no

Journal of Affective Disorders
|March 21, 2013
PubMed
Summary

Recurrent brief depression (RBD) patients show altered working memory networks. Those with hypomania history exhibit distinct insula activation, suggesting differing attention and memory abilities.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Recurrent brief depression (RBD) is characterized by depressive episodes without sustained mania.
  • Understanding the neurobiological underpinnings of working memory in RBD is crucial, especially differentiating subtypes with and without hypomanic episodes.
  • Previous research has not fully elucidated the working memory network differences in these specific patient groups.

Purpose of the Study:

  • To investigate how working memory load impacts the neural network associated with working memory in women with recurrent brief depression (RBD).
  • To compare brain activation patterns during working memory tasks between women with RBD and healthy controls.
  • To identify potential neurological differences between RBD patients with (RBD-H) and without (RBD-O) a history of hypomanic episodes.

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Related Experiment Videos

Last Updated: May 13, 2026

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
08:42

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Published on: May 19, 2015

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition
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Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition

Published on: February 1, 2012

Brain Imaging Investigation of the Neural Correlates of Emotional Autobiographical Recollection
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Main Methods:

  • fMRI scans were conducted on 33 medication-free, euthymic participants performing 1-back and 2-back working memory tasks.
  • Differential activation between tasks was analyzed globally and in seven predefined regions of interest.
  • Patient groups (RBD-H, RBD-O) were compared to age-, handedness-, and education-matched healthy women.

Main Results:

  • Both RBD groups exhibited poor task modulation in the prefrontal cortex (BA9) during the 1-back task.
  • The RBD-H subgroup showed distinct activation patterns during the 2-back task compared to the RBD-O subgroup.
  • Task modulation in the right parahippocampal gyrus (BA27) differentiated RBD-O, while the right insula differentiated RBD-H.

Conclusions:

  • Activation differences in BA9 and the parahippocampal region suggest varying functional hypersensitivity and attention/working memory abilities between RBD subgroups.
  • Lack of deactivation in the right insula among RBD patients mirrors findings in bipolar I disorder.
  • These findings may indicate distinct functional profiles differentiating RBD patients with and without hypomanic histories.