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Updated: May 13, 2026

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

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[Myopia in pseudoxanthoma elasticum].

A Trelohan1, D Milea, L Martin

  • 1Service d'ophtalmologie, CHU d'Angers, 2, rue Larrey, 49933 Angers cedex, France. lecq_anne@yahoo.fr

Journal Francais D'Ophtalmologie
|March 21, 2013
PubMed
Summary
This summary is machine-generated.

Pseudoxanthoma elasticum (PXE) is linked to mild myopia in patients compared to healthy individuals. This suggests potential ocular changes in PXE, warranting further investigation into its effects on vision.

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Published on: January 6, 2018

Area of Science:

  • Ophthalmology
  • Genetics
  • Dermatology

Context:

  • Pseudoxanthoma elasticum (PXE) is a rare genetic disorder affecting elastic fibers.
  • Ocular manifestations of PXE are not well-documented.
  • PXE shares similarities with Marfan syndrome, another collagen-vascular disease with known refractive errors.

Purpose:

  • To investigate the association between PXE and myopia.
  • To compare refractive errors in PXE patients with age- and sex-matched controls.

Summary:

  • A cross-sectional study of 53 PXE patients and 53 controls found a statistically significant difference in mean myopia.
  • PXE patients exhibited mild myopia (-0.98 D) compared to controls (-0.33 D).
  • No significant differences were observed in axial length, keratometry, or lens power between groups.

Impact:

  • PXE may be associated with mild myopia, potentially due to pathologic changes in zonular fibers causing lens displacement.
  • These findings highlight the need for further research, including larger cohorts and analysis of anterior chamber depth and zonular histology, to confirm the link between PXE and myopia.