Related Experiment Video
Updated: May 13, 2026

08:12
Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
Published on: March 29, 2018
Mercury from dental amalgams: exposure and effects
1Uddeholm Tooling AB, Hagfors, Sweden.
The International Journal of Risk & Safety in Medicine
|March 21, 2013
Summary
Mercury from dental amalgam fillings may significantly impact public health and quality of life. Exposure levels are higher than safe limits, warranting consideration for neurological and immunological diseases.
Area of Science:
- Environmental Health
- Toxicology
- Dental Materials Science
Background:
- Dental amalgam fillings are a widespread source of mercury exposure.
- Concerns exist regarding the long-term health effects of chronic, low-level mercury exposure from dental sources.
- Interprofessional collaboration between dental, medical, and environmental health sectors is often lacking.
Purpose of the Study:
- To review and discuss the risks associated with mercury exposure from dental amalgam fillings.
- To evaluate the contribution of amalgam-derived mercury to modern health problems and reduced quality of life.
- To assess mercury exposure levels relative to established safe limits and explore etiological links to diseases.
Main Methods:
- Comprehensive review of scientific literature across multiple disciplines.
- Analysis of biological and metallurgical evidence pertaining to mercury release from amalgam.
- Consideration of clinical experience spanning ten years in the field.
Main Results:
- Mercury from dental amalgam fillings may significantly contribute to various health issues and decreased quality of life.
- Typical mercury exposure levels from amalgam fillings are 5-10 times higher than safe limits for other mercury sources.
- Dental mercury exposure is a potential etiological factor for neurological, immunological, and endocrinological diseases of unknown origin.
Conclusions:
- The prevailing opinion of 'negligible' mercury exposure from dental amalgam is erroneous.
- Dental mercury exposure warrants serious consideration in the diagnosis of idiopathic neurological, immunological, and endocrinological conditions.
- Protective measures for amalgam removal and the development of alternative dental materials are crucial.
Related Concept Videos
The Periodic Table and Organismal Elements
Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...
Periodic Table Provides Information...
The Periodic Table and Organismal Elements
OverviewElements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally-occurring, and fewer still are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.The Periodic Table Provides Information...
Toxic Reactions: Overview
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Types of Toxins
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Biological Effects of Radiation
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...
Minerals
Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.

