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Related Concept Videos

Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's phenomenon, is a...
Decreased Body Temperature01:29

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without causing...
Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Methods of reducing fever01:22

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:

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Related Experiment Video

Updated: May 13, 2026

Quantitative Autonomic Testing
11:40

Quantitative Autonomic Testing

Published on: July 19, 2011

Pure autonomic failure with cold induced sweating.

Juan Idiaquez1, Ricardo Fadic, Renato Verdugo

  • 1Universidad de Valparaíso. School of Medicine, Valparaíso Chile. idiaquez@123.cl

Autonomic Neuroscience : Basic & Clinical
|March 21, 2013
PubMed
Summary
This summary is machine-generated.

Pure autonomic failure (PAF) patients may experience paradoxical sweating when exposed to cool temperatures. This suggests potential alterations in autonomic nerve responses to thermal stimuli in this neurodegenerative disorder.

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Last Updated: May 13, 2026

Quantitative Autonomic Testing
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Published on: July 19, 2011

Field-Based Thermal Physiology Assay: Cold Shock Recovery under Ambient Conditions
07:54

Field-Based Thermal Physiology Assay: Cold Shock Recovery under Ambient Conditions

Published on: March 9, 2021

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
06:43

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Published on: November 21, 2017

Area of Science:

  • Neurology
  • Autonomic Neuroscience

Background:

  • Pure autonomic failure (PAF) is a progressive neurodegenerative disorder affecting the autonomic nervous system.
  • Previous reports linked cold-induced sweating to specific genetic mutations (CRLF1, CLCF1) or cervical dissection.

Observation:

  • A patient diagnosed with PAF presented with sweating induced by cool ambient temperatures (18°C).
  • This patient exhibited severe orthostatic hypotension, abnormal cardiovagal reflexes, and paradoxical upper trunk sweating.
  • Skin biopsy revealed involvement of somatic epidermal unmyelinated nerve fibers, and sensory testing showed widespread thermal sensory deficits.

Findings:

  • The observed paradoxical sweating in PAF suggests an atypical sudomotor response to cold.
  • Quantitative sensory testing indicated significant abnormalities across all thermal sensory modalities.

Implications:

  • The findings suggest potential mechanisms involving cold-induced noradrenaline release and heightened sudomotor sensitivity in remaining autonomic nerves.
  • This case expands the understanding of thermoregulatory dysfunction in Pure Autonomic Failure.
  • Further research is warranted to explore the neurophysiological basis of these responses in autonomic neurodegenerative disorders.