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Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Drug Distribution: Plasma Protein Binding01:29

Drug Distribution: Plasma Protein Binding

Drugs predominantly attach to plasma proteins, with only a small percentage remaining unbound. The unbound portion can be calculated as one minus the bound fraction. Acidic drugs form large, inactive complexes by reversibly binding to plasma albumin, which prevents them from diffusing across biological barriers. These drug-protein complexes act as reservoirs for the drugs. As the concentration of unbound drugs decreases, these complexes quickly dissociate to release the free drug, maintaining...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Overview of Fatty Acid Metabolism01:28

Overview of Fatty Acid Metabolism

Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
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Hepatic Drug Clearance: Effect of Protein Binding01:09

Hepatic Drug Clearance: Effect of Protein Binding

Hepatic clearance is influenced by protein binding based on the drug's extraction ratio. Drugs with high extraction ratios are considered flow-limited and remain unaffected by protein binding during hepatic clearance. On the other hand, drugs with low extraction ratios may be impacted by plasma protein binding, although the extent of this influence depends on the fraction of the drug bound.
For low-extraction-ratio drugs that are less than 80% protein-bound, minor changes in protein binding...

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Updated: May 13, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
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Published on: November 24, 2020

Alcohol and plasma triglycerides.

Boudewijn Klop1, Ana Torres do Rego, Manuel Castro Cabezas

  • 1Department of Internal Medicine, Sint Franciscus Gasthuis Rotterdam, the Netherlands.

Current Opinion in Lipidology
|March 21, 2013
PubMed
Summary
This summary is machine-generated.

High alcohol intake elevates plasma triglycerides, increasing risks for cardiovascular disease and pancreatitis. Moderate consumption may lower triglycerides, influenced by beverage type and genetics. Patients with hypertriglyceridemia should limit alcohol.

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Area of Science:

  • Metabolic studies
  • Cardiovascular research
  • Nutritional science

Background:

  • Alcohol consumption and fat intake are linked via hypothalamic signals and cephalic responses.
  • A J-shaped curve describes the relationship between alcohol intake and plasma triglycerides.
  • Factors like normal body weight, red wine polyphenols, and specific gene variants (apolipoprotein A-V, apolipoprotein C-III) may offer protection against alcohol-related hypertriglyceridemia.

Purpose of the Study:

  • To review recent developments on alcohol's effects on plasma triglycerides.
  • To focus on population, intervention, and metabolic studies concerning alcohol and plasma triglycerides.

Main Methods:

  • Review of population studies.
  • Review of intervention studies.
  • Review of metabolic studies.

Main Results:

  • Obesity exacerbates alcohol-associated hypertriglyceridemia, increasing pancreatitis risk.
  • High alcohol intake is linked to elevated plasma triglycerides, cardiovascular disease, alcoholic fatty liver disease, and pancreatitis.
  • Light to moderate alcohol consumption may correlate with decreased plasma triglycerides, influenced by beverage type, genetics, and lifestyle.

Conclusions:

  • Alcohol-induced hypertriglyceridemia results from increased VLDL secretion, impaired lipolysis, and enhanced free fatty acid flux to the liver.
  • Despite potential benefits of moderate consumption, high alcohol intake remains detrimental.
  • Patients with hypertriglyceridemia should be advised to reduce or cease alcohol consumption.