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Assessment of small bowel motility in patients with chronic intestinal pseudo-obstruction using cine-MRI

Hidenori Ohkubo1, Takaomi Kessoku, Akiko Fuyuki

  • 1Gastroenterology Division, Yokohama City University School of Medicine, Yokohama, Japan.

The American Journal of Gastroenterology
|March 21, 2013
PubMed
Abstract

Insights

Cine-magnetic resonance imaging (MRI) effectively diagnoses chronic intestinal pseudo-obstruction (CIPO) by revealing impaired small bowel motility. This non-invasive technique offers a new diagnostic tool for CIPO patients.

Area of Science:

  • Gastroenterology
  • Medical Imaging
  • Motility Disorders

Background:

  • Chronic intestinal pseudo-obstruction (CIPO) is a severe, rare motility disorder with potentially life-threatening complications.
  • Current diagnostic methods for CIPO are often invasive, leading to diagnostic delays.
  • Cine-magnetic resonance imaging (MRI) is an emerging non-invasive technique for evaluating whole-bowel motility.

Purpose of the Study:

  • To compare small bowel motility in healthy volunteers, irritable bowel syndrome (IBS) patients, and CIPO patients using cine-MRI.
  • To evaluate the diagnostic utility of cine-MRI for CIPO.

Main Methods:

  • Prospective cine-MRI scans were performed on 12 healthy volunteers, IBS patients, and CIPO patients at 1.5 Tesla.
  • Measurements included luminal diameter, contraction ratio, and contraction cycle of the small bowel.
  • Parameters were compared between the three groups.

Main Results:

  • Cine-MRI successfully provided dynamic images of small bowel motility.
  • CIPO patients exhibited significantly larger luminal diameters (43.4±14.1 mm) compared to healthy volunteers (11.1±1.5 mm) and IBS patients (10.9±1.9 mm).
  • CIPO patients showed a significantly lower contraction ratio (17.1±11.0%) than healthy volunteers (73.0±9.3%) and IBS patients (74.6±9.4%). No significant difference was found in contraction cycle.

Conclusions:

  • This study demonstrates the clinical utility of cine-MRI in diagnosing CIPO.
  • Cine-MRI effectively detects impaired contractility in CIPO patients.
  • As a non-invasive, radiation-free method that visualizes the entire small bowel, cine-MRI is a promising tool for CIPO diagnosis and follow-up.

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