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Treatment of hypertension as a risk factor in a prospective study

H L Thürmer1, P G Lund-Larsen, A Tverdal

  • 1National Health Screening Service, Oslo, Norway.

The International Journal of Risk & Safety in Medicine
|March 21, 2013
PubMed

Insights

Blood pressure treatment in a real-world setting was linked to higher mortality rates. This study suggests treatment outcomes may be worse than in clinical trials, especially for those on medication.

Area of Science:

  • Cardiovascular epidemiology
  • Public health research
  • Clinical outcomes analysis

Background:

  • Blood pressure management is crucial for cardiovascular health.
  • Real-world effectiveness of hypertension treatment requires ongoing investigation.
  • Previous studies often focus on controlled clinical trial data.

Purpose of the Study:

  • To examine the association between blood pressure treatment, blood pressure levels, and mortality.
  • To compare mortality risks in individuals receiving blood pressure medication versus those not treated.
  • To investigate the relationship between blood pressure and mortality, considering cardiovascular risk factors.

Main Methods:

  • A 12-year follow-up study of a cardiovascular risk factor screening.
  • Inclusion of 33,154 men and 16,407 women aged 40-49 with complete blood pressure and treatment data.
  • Analysis of mortality from coronary heart disease, stroke, and all causes, stratified by treatment status and blood pressure levels.

Main Results:

  • Individuals on blood pressure medication showed significantly higher mortality from cardiovascular disease and all causes.
  • A J-shaped association between blood pressure and mortality was observed in the treated group.
  • Excess mortality was noted even after accounting for previous myocardial infarction or stroke.

Conclusions:

  • Blood pressure treatment in this population was associated with increased all-cause mortality.
  • Real-world treatment outcomes may be inferior to those reported in controlled clinical trials.
  • A J-shaped relationship between blood pressure and mortality exists for men on treatment.

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