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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
[Epstein-Barr virus-associated lymphoproliferations and lymphomas]
1Institut für Pathologie, Charité Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, 10117 Berlin, Deutschland. ioannis.anagnostopoulos@charite.de
Der Pathologe
|March 21, 2013
Summary
Epstein-Barr virus (EBV), a common herpesvirus, can cause various B-cell lymphoproliferations and lymphomas in immunocompromised individuals. Accurate classification of these EBV-associated lesions relies on clinical data and specific immunohistological markers.
Area of Science:
- Virology
- Immunology
- Pathology
Background:
- Epstein-Barr virus (EBV) infects over 95% of the global population.
- EBV can cause lymphoproliferative disorders and lymphomas in immunocompromised individuals.
- These EBV-associated lesions range from benign hyperplasia to aggressive lymphomas.
Purpose of the Study:
- To summarize the spectrum of EBV-associated lymphoproliferations and lymphomas.
- To highlight the diagnostic challenges and key features of these lesions.
- To emphasize the importance of diagnostic tools for precise classification.
Main Methods:
- Review of clinical data and histopathological findings.
- Immunohistochemical detection of CD30 expression.
- Demonstration of EBV-encoded proteins and RNA transcripts.
Main Results:
- EBV-associated lesions present with diverse B-cell subsets, often extranodal.
- Histology is typically polymorphous, showing angioinvasion and necrosis.
- CD30 expression and EBV detection aid in classification.
Conclusions:
- EBV is a significant oncogenic factor in lymphoproliferative diseases.
- A combination of clinical, histological, and molecular data is crucial for diagnosis.
- Accurate classification of EBV-driven lymphomas is essential for patient management.
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