PEGylation-aided refolding of globular adiponectin

Mingming Gao1, Yue Tong, Xiangdong Gao

  • 1State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Tongjiaxiang 24, Nanjing 210009, China.

Summary

Globular adiponectin (GAD) refolding for diabetes drug development was improved using polyethylene glycol (PEG) conjugation. This novel PEGylation-aided method efficiently refolded GAD, restoring its glucose-lowering activity in mice.

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