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Related Experiment Video

Updated: May 13, 2026

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

Published on: March 28, 2025

Severe neonatal hypernatraemia: a population based study.

Sam Joseph Oddie¹, Vanessa Craven, Kathryn Deakin

¹Bradford Neonatology, Bradford Royal Infirmary, West Yorkshire, UK. Sam.oddie@bthft.nhs.uk

Archives of Disease in Childhood. Fetal and Neonatal Edition

|March 21, 2013

Summary

This summary is machine-generated.

Severe neonatal hypernatraemia (SNH) is uncommon and strongly linked to weight loss during breastfeeding attempts. Most infants recover well without serious short-term complications, requiring only hospitalization.

Keywords:

Breastfeeding Dehydration Hypernatraemia Patient readmission Weight loss

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Last Updated: May 13, 2026

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

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Published on: March 28, 2025

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Published on: August 25, 2022

Area of Science:

Neonatology
Pediatric Endocrinology
Public Health Surveillance

Background:

Severe neonatal hypernatraemia (SNH), defined as serum sodium ≥160 mmol/l, poses a significant clinical challenge.
Understanding the incidence, presentation, and outcomes of SNH is crucial for timely intervention and prevention strategies.

Purpose of the Study:

To determine the incidence of SNH in a defined population.
To describe the clinical presentation, management, and short-term outcomes of infants with SNH.

Main Methods:

A prospective, population-based surveillance study was conducted over 13 months.
Data were collected via the British Paediatric Surveillance Unit for infants >33 weeks gestation, fed breast or formula milk, and presenting <28 days of age.

Main Results:

The incidence of SNH was 7 per 100,000 live births, with 61 of 62 cases linked to attempted exclusive breastfeeding.
Infants presented with significant weight loss (median 19.5%), with 58% losing ≥15% of birth weight.
No deaths, seizures, or coma were reported; infants recovered with a median hospital stay of 5 days.

Conclusions:

Severe neonatal hypernatraemia is strongly associated with excessive weight loss in neonates attempting to breastfeed.
While uncommon, SNH in this cohort did not appear to be associated with severe short-term morbidities beyond hospitalization.
Emphasis on monitoring infant weight and hydration during the initiation of breastfeeding is warranted.