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Non-dipping phenomenon in children with monosymptomatic nocturnal enuresis

Aydin Kahraman1, Hasan Dursun, Sami Hatipoglu

  • 1Division of Pediatrics, Dr Sadi Konuk Teaching and Medical Research Hospital, Istanbul, Turkey.

Pediatric Nephrology (Berlin, Germany)
|March 21, 2013
PubMed

Insights

Children with monosymptomatic nocturnal enuresis often have elevated nocturnal blood pressure and a reduced day-to-night blood pressure difference. This "non-dipping" phenomenon may contribute to the development of enuresis nocturna.

Area of Science:

  • Pediatric Nephrology
  • Cardiology
  • Sleep Medicine

Background:

  • Monosymptomatic nocturnal enuresis is a common childhood condition with complex etiopathogenesis.
  • Understanding contributing factors is crucial for effective management, especially for treatment-resistant cases.

Purpose of the Study:

  • To investigate the association between nocturnal enuresis and 24-hour blood pressure profiles in children.
  • To explore potential systemic factors contributing to enuresis nocturna.

Main Methods:

  • Ambulatory blood pressure monitoring over 24 hours in 45 children with monosymptomatic nocturnal enuresis and 22 healthy controls.
  • Comprehensive medical tests including blood counts, biochemistry, urinalysis, renin-aldosterone levels, and abdominal ultrasound.

Main Results:

  • Children with nocturnal enuresis exhibited significantly higher nocturnal blood pressure levels compared to controls.
  • A significantly lower day-to-night blood pressure difference (non-dipping) was observed in enuretic children.

Conclusions:

  • Nocturnal enuresis may involve systemic factors beyond the urinary system.
  • A non-dipping blood pressure profile is identified as a potential contributing factor in the pathogenesis of enuresis nocturna.
  • Systemic evaluation is recommended for enuresis cases resistant to initial therapies.
Abstract

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