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Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: May 13, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Cancer cachexia--pathophysiology and management.

Hajime Suzuki1, Akihiro Asakawa, Haruka Amitani

  • 1Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.

Journal of Gastroenterology
|March 21, 2013
PubMed
Summary
This summary is machine-generated.

Cancer cachexia, a syndrome of anorexia and muscle loss affecting half of cancer patients, significantly impacts quality of life and survival. Multifactorial treatments and novel therapies show promise for managing this serious complication.

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Last Updated: May 13, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Area of Science:

  • Oncology
  • Metabolic Disorders
  • Physiology

Background:

  • Cachexia affects approximately 50% of cancer patients, characterized by anorexia and significant loss of adipose and skeletal muscle mass.
  • This syndrome profoundly impacts patient quality of life, dignity, and survival, often leading to increased chemotherapy side effects and reduced treatment completion.
  • Cytokines are implicated in cancer cachexia, potentially mimicking leptin signaling and suppressing appetite hormones like ghrelin and neuropeptide Y (NPY).

Purpose of the Study:

  • To review the role of cytokines in cancer cachexia.
  • To discuss the mechanisms of cancer-related muscle wasting.
  • To explore current and emerging treatment strategies for cachexia.

Main Methods:

  • Literature review of studies on cancer cachexia mechanisms and treatments.
  • Analysis of the role of cytokines, anorexia, and muscle wasting in cancer.
  • Examination of various therapeutic agents and supportive care measures.

Main Results:

  • Cytokines contribute to anorexia and muscle wasting through complex mechanisms, including protein synthesis inhibition and increased degradation.
  • Numerous drugs, such as appetite stimulants, thalidomide, and cytokine inhibitors, have been investigated for cachexia treatment.
  • Supportive care and novel pharmaceutical agents offer a growing positive impact on managing cachexia.

Conclusions:

  • Cancer cachexia is a complex syndrome requiring multifactorial treatment approaches.
  • Understanding the biological mechanisms of cachexia is advancing, alongside the development of promising new therapies.
  • Healthcare providers must address the significant psychosocial and biomedical impacts of cachexia on patients.