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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
Chronological decrease of tuberculosis incidence rates by organ classification based on a birth cohort study in
Nobuharu Ohshima1, Hirotoshi Matsui, Naohiro Nagayama
1Asthma and Allergy Center, National Hospital Organization Tokyo National Hospital, Tokyo, Japan. ohshima-in@tokyo-hosp.jp
Kekkaku : [Tuberculosis]
|March 22, 2013
Summary
Tuberculosis (TB) reactivation in elderly Japanese individuals primarily stems from youth infections. Post-stationary phase, TB incidence rates in organs like lymph nodes, bones, kidneys, and meninges remain constant, indicating persistent endogenous reactivation.
Area of Science:
- Epidemiology
- Infectious Diseases
- Public Health
Background:
- Tuberculosis (TB) incidence has declined in Japan post-WWII due to medical, nutritional, and hygiene advancements.
- Current high TB rates in the elderly suggest reactivation of infections acquired during youth.
- TB reactivation presents common and unique characteristics across different organs.
Purpose of the Study:
- To evaluate the frequency of endogenous TB reactivation in various organs.
- To analyze TB incidence rates over a 30-year period (1975-2005) in Japan.
Main Methods:
- Analysis of newly registered TB patient data from 1975, 1985, 1995, and 2005 in Japan.
- Calculation of TB incidence rates per 10-year birth cohort for specific organs.
- Inclusion of pulmonary, lymph node, bone-joint, kidney, and meninges TB in the analysis.
Main Results:
- TB incidence rates showed a declining then stationary phase for all organs except pulmonary TB.
- In the stationary phase, incidence rates per 100,000 cases were: lymph node TB (3.0), bone-joint TB (1.2), kidney TB (0.5), and meninges TB (0.3).
Conclusions:
- The incidence rate of TB in specific organs, once infected, does not decline below established stationary phase levels.
- These findings highlight the long-term implications of endogenous TB reactivation in the elderly population.
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