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Updated: May 13, 2026

Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
Breastfeeding and metabolic indicators in Mexican premature newborns
Rebeca Monroy-Torres1, Jaime Naves-Sánchez, Juan Antonio Ortega-García
1Universidad de Guanajuato, Departamento de Medicina y Nutrición, División de Ciencias de la Salud, Campus León. rmonroy79@yahoo.com.mx
Insights
Premature infants often have poor weight gain and altered metabolic markers. Prolonging breastfeeding and extending follow-up can improve growth and development in these vulnerable infants.
Area of Science:
- Neonatal nutrition
- Pediatric metabolic health
- Infant growth and development
Background:
- Preterm infants face higher morbidity and mortality due to physiological immaturity.
- Nutritional interventions are crucial for weight gain, supporting growth, neurological development, and preventing metabolic complications.
- Breastfeeding duration's impact on preterm infants was analyzed in the first six months of life.
Purpose of the Study:
- To evaluate the effects of nutritional and metabolic markers in preterm infants.
- To assess growth indicators and metabolic parameters at the end of the first semester of life.
Main Methods:
- An analytical, transversal, and comparative study of 100 preterm infants (30-36 weeks gestational age).
- Measured weight, length, and head circumference at birth and 6-9 months follow-up.
- Assessed metabolic indicators including glucose, hemoglobin, cholesterol, triglycerides, insulin, urea, creatinine, gamma-glutamyl-transferase, and alkaline phosphatase.
Main Results:
- Significant differences were observed in hemoglobin, creatinine, and urea levels compared to reference values.
- Average breastfeeding duration was 4.3 months.
- Identified risk factors for hypercholesterolemia and noted significant differences in hemoglobin, creatinine, and urea.
Conclusions:
- Preterm infants exhibited weight gain deficiencies.
- Biochemical parameters indicate potential metabolic risks.
- Recommendations include prolonged breastfeeding and extended infant follow-up for monitoring growth and development post-hospitalization.
Background:
Morbidity and mortality rates are higher among preterm infants due to physiological immaturity and greater growth demands. Nutritional intervention contributes to proper weight gain, which translates into better growth and neurological development, and prevents the onset of metabolic complications. The effect of breastfeeding duration was studied in the analytic profile at the end of the first six months of life.
Objective:
To describe the nutritional and metabolic markers effect in preterm infants at the end of the first semester of life.
Material And Methods:
We performed an analytical, transversal and comparative study in 100 preterm infants, 30 to 36 weeks gestational age. Measures for weight, length and head circumference at birth were taken from the subjects' clinical files. A follow-up conducted at 6 to 9 months of age evaluated the same nutritional indicators (weight, length, head circumference) and compared them with values at birth and recommendations. Metabolic indicators (glucose, hemoglobin, cholesterol, triglycerides, insulin, urea, creatinine, gamma-glutamyl-transferase and alkaline phosphatase) were compared with the recommendations. Follow-up study in 100 preterm infants (30 to 36 weeks gestational age). Weight, length and head circumference were measured at birth and 6 to 9 months later. We measured analytic parameters related to metabolic syndrome (glucose, hemoglobin, cholesterol, triglycerides, insulin, urea, creatinine, gamma-glutamyl transferase and alkaline phosphatase). Confusing factors like income level and access to public services were also studied.
Results:
The mean age at follow-up was 7.3 +/- 1.4 months. Levels of hemoglobin, creatinine and urea showed significant differences with regard to reference values (Wilcoxon ranks test, < 0.05). The average duration of breastfeeding was 4.3 months. The mean age at follow-up was 7.3 +/- 1.4 months. Risk factors for hypercholesterolemia, as well as levels of hemoglobin, creatinine and urea showed significant differences with regard to reference values (Wilcoxon ranks test, < 0.05).
Conclusions:
Premature infants showed deficiencies in weight gain. Biochemical parameters could reflect metabolic risk, therefore we recommend prolonging breastfeeding as well as extending the follow-up of these infants for monitoring their growth and development once out of the hospital.
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