Related Experiment Video
Updated: May 13, 2026

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
Published on: July 11, 2025
Antiplasmodial activity of compounds from the surface exudates of Senecio roseiflorus
Leonidah Omosa Kerubo1, Jacob Ogweno Midiwo, Solomon Derese
1Department of Chemistry, Nairobi University, P Bag 30197-00100, Nairobi, Kenya.
Abstract:
From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized. The structures of these compounds were determined on the basis of their spectroscopic analysis. The surface exudate and the flavonoids isolated showed moderate to good antiplasmodial activity with 5,4'-dihydroxy-7-dimethoxyflavanone having the highest activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum, with IC50 values of 3.2 +/- 0.8 and 4.4 +/- 0.01 microg/mL respectively.
Related Concept Videos
Anthelminthic Agents
Antifungal Agents