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Evolving patterns of tissue composition in benign prostatic hyperplasia as a function of specimen size
H Price1, J E McNeal, T A Stamey
1Division of Urology, Stanford University School of Medicine, CA.
Human Pathology
|June 1, 1990
Summary
Benign prostatic hyperplasia (BPH) tissue composition varies significantly with specimen weight. Epithelial-rich nodules are the most rapidly evolving component in BPH, dominating larger specimens.
Area of Science:
- Urology
- Pathology
- Medical Imaging
Background:
- Benign prostatic hyperplasia (BPH) is a common condition in aging men.
- Understanding the tissue composition of resected BPH is crucial for treatment.
- Previous studies have not fully characterized the morphologic heterogeneity of BPH tissue.
Purpose of the Study:
- To quantitate the tissue composition of BPH specimens.
- To analyze morphologic changes in relation to specimen weight.
- To identify the dominant hyperplastic components in BPH.
Main Methods:
- Computerized morphometric analysis of 36 transurethral resections and 4 prostate enucleations.
- Categorization of tissue into 15 morphologic types.
- Comparison of tissue composition across seven weight ranges.
Main Results:
- BPH tissue is heterogeneous, with composition varying by weight.
- Nodules comprised most tissue only in specimens >50g.
- Non-nodular transition zone tissue was dominant in smaller resections.
- Epithelial-rich glandular nodules were the most common hyperplastic component.
- Nodules showed the most rapid increase in contribution to hyperplasia with increasing weight.
Conclusions:
- BPH tissue composition evolves morphologically with increasing specimen weight.
- Histologically normal tissue is the most common hyperplastic component.
- Epithelial-rich nodules represent the most dynamic component of BPH.