Related Experiment Video
Updated: May 13, 2026

Clean Sampling and Analysis of River and Estuarine Waters for Trace Metal Studies
Published on: July 1, 2016
Best practices for single-laboratory validation of chemical methods for trace elements in foods. Part I--background
Cory J Murphy1, James D MacNeil, Stephen G Capar
1Canadian Food Inspection Agency, Dartmouth Laboratory, 1992 Agency Drive, Dartmouth, Nova Scotia, Canada, B3B 1Y9. Cory.Murphy@inspection.gc.ca
Abstract:
The metals subgroup of AOAC INTERNATIONAL's Community on Chemical Contaminants and Residues in Food has been engaged for the past several years in discussions concerning the requirements for the single-laboratory validation (SLV) of methods for the determination of trace elements in foods. This paper reviews the general guidance currently available related to validation of chemical analytical methods and current typical validation practices found in publications on the analysis of elements in food and other matrixes, such as environmental and clinical samples. Based on the available guidance on SLV requirements and a review of current practices in elemental analysis, a general approach based on best practices is proposed for SLV of a method for elements in food to demonstrate the method as "fit-for-purpose."
More Related Videos
Related Concept Videos
Data Validation
Key parameters for method validation include:
Atomic Absorption Spectroscopy: Lab
Solutions containing organic solvents, such as low-molecular-mass alcohols, esters, or ketones, enhance absorbances by increasing nebulizer...
Sample Preparation for Analysis: Overview
Bulk or large solid samples are typically reduced in size using grinding, crushing, or milling techniques to increase the...
Sample Preparation for Analysis: Advanced Techniques
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
Voltammetry: Stripping Methods
Anodic Stripping Voltammetry (ASV)
ASV is used to determine metals and metalloids at trace levels. It involves two steps: deposition and stripping. First, a negative potential is applied to the...
Atomic Emission Spectroscopy: Overview

