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Tenolol in angina pectoris.

L S Shah1, S A Merchant, S F Padaria

  • 1K.E.M. Hospital, Bombay.

Indian Heart Journal
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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Tenolol, a selective beta-blocker, significantly reduced angina attacks and improved ST depression in patients with angina pectoris. Both 50 mg and 100 mg doses demonstrated efficacy over a four-week trial.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Angina pectoris management remains a clinical challenge.
  • Selective beta-blockers offer a therapeutic option for cardiovascular conditions.

Purpose of the Study:

  • To evaluate the efficacy and safety of Tenolol (a selective beta-blocker) in patients with angina pectoris.
  • To assess the impact of two different dosages (50 mg and 100 mg) on angina symptoms and objective markers.

Main Methods:

  • A 4-week single-dose drug therapy trial involving 25 patients with angina pectoris (hypertensives excluded).
  • Patients received either Tenolol 50 mg (A50) or 100 mg (A100).
  • Subjective (angina attacks) and objective (Computerised Stress Test - CST, ST depression, systolic blood pressure, double product) assessments were performed.

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Main Results:

  • Statistically significant reduction in angina attacks observed with both A50 and A100.
  • Significant improvement in ST depression noted during CST for both dosages.
  • Significant decrease in systolic blood pressure and double product was recorded.

Conclusions:

  • Tenolol (50 mg and 100 mg) is effective in managing angina pectoris, showing significant improvements in subjective and objective parameters.
  • The drug demonstrated a favorable safety profile with only minor adverse events reported.