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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
Post-traumatic vancomycin-resistant enterococcal endophthalmitis
Roxane J Hillier1, Parnian Arjmand, Gabriel Rebick
1Ophthalmology Department, St Michael's Hospital, 801-61 Queen Street East, Toronto, ON, M5C 2T2, Canada. roxanehillier@gmail.com.
Abstract:
The emergence of antibiotic-resistant organisms among severe ocular infections is of grave concern. We describe the first reported case of vancomycin-resistant enterococcal endophthalmitis following ocular trauma, uniquely caused by Enterococcus gallinarum. The organism demonstrated intrinsic resistance to ceftazidime and vancomycin but responded favorably to a combination of intravitreal and intravenous ampicillin, plus intravitreal amikacin. When faced with a multidrug-resistant organism, the ophthalmologist must consider alternative antibiotic strategies.
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