Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Peripheral Artery Disease I: Introduction

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

Pharmacogenomics: Identification of New Drug Targets

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cross-omics analysis revealed gut microbiome-related metabolic pathways underlying atherosclerosis development after antibiotics treatment.

Molecular metabolism·2020

Same author

Electrothermal patches driving the transdermal delivery of insulin.

Nanoscale horizons·2020

Same author

Incretin combination therapy for the treatment of non-alcoholic steatohepatitis.

Diabetes, obesity & metabolism·2020

Same author

Pirfenidone Is an Agonistic Ligand for PPARα and Improves NASH by Activation of SIRT1/LKB1/pAMPK.

Hepatology communications·2020

Same author

Microbiome Modulation of the Host Adaptive Immunity through Bile Acid Modification.

Cell metabolism·2020

Same author

Analysis of the association of MPO and MMP-9 with stroke severity and outcome: Cohort study.

Neurology·2020

Search research articles

Related Experiment Video

Updated: May 13, 2026

Characterizing Modulators of Protease-Activated Receptors with a Calcium Mobilization Assay Using a Plate Reader

Characterizing Modulators of Protease-Activated Receptors with a Calcium Mobilization Assay Using a Plate Reader

Published on: May 24, 2024

PPARs: a potential target for a disease-modifying strategy in stroke.

Thavarak Ouk¹, Camille Potey, Sophie Gautier

¹EA 1046 - Département de Pharmacologie médicale, University Lille Nord de France, Université de Lille 2 - Faculté de Médecine, Centre Hospitalier Universitaire, Institut de Médecine Prédictive et de Recherche Thérapeutique, Lille, France.

Current Drug Targets

|March 22, 2013

Summary

Peroxisome proliferator-activated receptors (PPARs) show potential as disease-modifying drugs for stroke. These nuclear receptors may offer neuroprotection and limit long-term consequences, addressing a critical need in stroke treatment.

Related Experiment Videos

Last Updated: May 13, 2026

Characterizing Modulators of Protease-Activated Receptors with a Calcium Mobilization Assay Using a Plate Reader

Characterizing Modulators of Protease-Activated Receptors with a Calcium Mobilization Assay Using a Plate Reader

Published on: May 24, 2024

Area of Science:

Neuroscience
Pharmacology
Cardiovascular Research

Background:

Stroke is a leading cause of adult mortality and disability, with limited pharmacological treatments beyond thrombolysis.
Cerebral ischemia impacts the entire neurovascular unit, necessitating comprehensive therapeutic strategies.
Current treatments lack disease-modifying agents for neuroprotection and mitigating long-term stroke effects.

Purpose of the Study:

To review the potential of Peroxisome Proliferator-Activated Receptors (PPARs) and their agonists in stroke treatment.
To explore the role of individual PPAR receptors in the pathophysiology of cerebral ischemia.
To assess PPARs as potential disease-modifying drugs for stroke.

Main Methods:

Review of preclinical and clinical studies on PPARs in the context of stroke.
Analysis of PPAR expression within the neurovascular unit.
Examination of PPARs' interference with stroke-related pathways.

Main Results:

PPARs are nuclear receptors expressed in the neurovascular unit, suggesting a role in stroke.
PPARs can modulate pathways involved in cerebral ischemia.
PPAR agonists demonstrate potential for neuroprotection and reducing hemorrhagic risk.

Conclusions:

PPARs represent a promising therapeutic target for stroke.
PPAR agonists could serve as adjuvants to thrombolysis and address long-term stroke consequences.
Targeting PPARs offers a potential strategy for disease modification in stroke.