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Bioavailability of quercetin: problems and promises.
1Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan 250012, China.
Current Medicinal Chemistry
|March 22, 2013
Summary
Quercetin (QC) shows therapeutic promise but suffers from poor bioavailability. Novel drug delivery systems are enhancing QC solubility and absorption, paving the way for its wider pharmaceutical application.
Area of Science:
- Pharmacology and Drug Delivery
- Natural Products Chemistry
Background:
- Quercetin (QC) is a plant flavonoid with significant anti-inflammatory, antioxidant, anti-cancer, anti-anaphylaxis, and anti-aging properties.
- Pharmaceutical application of QC is hindered by its poor solubility, low bioavailability, poor permeability, and instability.
Purpose of the Study:
- To review and highlight strategies for improving the bioavailability of quercetin.
- To discuss the potential of advanced drug delivery systems in enhancing quercetin's therapeutic efficacy.
Main Methods:
- Literature review of studies focusing on quercetin bioavailability enhancement.
- Analysis of various drug delivery systems including inclusion complexes, liposomes, nanoparticles, and micelles for quercetin delivery.
Main Results:
- Drug delivery systems significantly improve quercetin's solubility and bioavailability.
- These systems overcome the limitations of poor permeability and instability associated with quercetin.
Conclusions:
- Enhanced bioavailability of quercetin through advanced drug delivery systems is crucial for its therapeutic potential.
- Improved quercetin delivery is expected to position it as a leading therapeutic agent for various human diseases.
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