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Related Experiment Video

Updated: May 13, 2026

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

Galectin-9 in cancer therapy.

Shintaro Fujihara¹, Hirohito Mori, Hideki Kobara

¹Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa, Japan. sannai@kms.ac.jp

Recent Patents on Endocrine, Metabolic & Immune Drug Discovery

|March 22, 2013

Summary

Galectin-9, a protein involved in immune responses, shows anti-cancer properties by inhibiting tumor cell proliferation and preventing metastasis. Its interaction with Tim-3 receptor impacts T cell function, offering therapeutic potential.

Related Experiment Videos

Last Updated: May 13, 2026

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

Area of Science:

Immunology
Molecular Biology
Oncology

Background:

Galectin-9 is a tandem-repeat galectin with two carbohydrate-recognition domains.
Initially identified as an eosinophil chemoattractant, galectin-9 modulates cell aggregation, adhesion, and tumor cell apoptosis.
Recent research highlights galectin-9's anti-proliferative effects on cancer cells.

Purpose of the Study:

To review the biology and physiological role of galectin-9.
To discuss the therapeutic potential of galectin-9 in cancer treatment.
To explore relevant patents concerning galectin-9 in oncology.

Main Methods:

Literature review of galectin-9 biology and function.
Analysis of studies on galectin-9's role in cancer cell proliferation and metastasis.
Examination of research on galectin-9's interaction with T cell immunoglobulin mucin-3 (Tim-3).

Main Results:

Galectin-9 exhibits anti-proliferative effects on cancer cells.
Loss of galectin-9 expression correlates with metastatic progression in solid cancers.
Recombinant galectin-9 prevents metastatic spread in preclinical cancer models.
Galectin-9, via Tim-3, negatively regulates T cell responses, promoting CD8+ T cell exhaustion and myeloid-derived suppressor cell expansion.

Conclusions:

Galectin-9 plays a significant role in regulating immune responses and tumor progression.
Galectin-9 demonstrates considerable therapeutic potential for cancer treatment.
Understanding galectin-9's mechanisms offers new avenues for cancer immunotherapy.