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Thyroid hormones-mediated effects of insulin on antioxidant enzymes from diabetic rat hearts

F Kosova1, N Altan, A Sepici

  • 1Celal Bayar University School of Health, Manisa, Turkey. fundakosova@gmail.com

Bratislavske Lekarske Listy
|March 22, 2013
PubMed

Insights

Thyroid hormones may help reverse diabetes-induced oxidative stress in rat hearts. This study shows thyroid hormones aid insulin in normalizing antioxidant enzyme activity and lipid peroxidation in diabetic rats.

Area of Science:

  • Biochemistry
  • Endocrinology
  • Cardiovascular Science

Background:

  • Oxidative stress from free radicals is implicated in diabetes and its complications.
  • Antioxidant enzymes and lipid peroxidation are altered in diabetic conditions.

Purpose of the Study:

  • To investigate the role of thyroid hormones in modulating antioxidant enzyme activities and lipid peroxidation in diabetic rat hearts.
  • To determine if thyroid hormones can reverse diabetes-induced cardiac oxidative stress.

Main Methods:

  • Experimentally induced diabetes in rats using streptozotosin (STZ).
  • Measurement of antioxidant enzyme activities (SOD, CAT, GSH-Px) and lipid peroxidation products (FOX, MDA) in cardiac tissues.
  • Assessment before and after thyroidectomy, with and without insulin and thyroid hormone treatments.

Main Results:

  • Diabetes, hypothyroidism, and combined conditions increased CAT and GPx activities and FOX and MDA levels.
  • Thyroid hormone treatments, along with insulin, regulated these alterations in a dose-dependent manner.
  • Thyroid hormones demonstrated a potential contribution to insulin's normalizing effect on diabetic cardiac changes.

Conclusions:

  • Thyroid hormones play a role in normalizing diabetes-induced oxidative stress and lipid peroxidation in rat cardiac tissue.
  • Thyroid hormone therapy may be a supportive strategy in managing diabetic cardiac complications.
  • Further research is warranted to elucidate the precise mechanisms of thyroid hormone action in diabetic cardiomyopathy.

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