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A Periprosthetic Joint Candida albicans Infection Model in Mouse
Published on: February 2, 2024
[Haematogenous infection of a prosthetic joint]
Huub J L van der Heide1, H M J Enrike van der Linden, Tom W J Huizinga
1Afd. Orthopedie, Leids Universitair Medisch Centrum, Leiden, the Netherlands. h.j.l.van_der_heide@lumc.nl
Abstract:
Prosthetic joint infection (PJI) is a major complication after total joint arthroplasty. The most common source of these PJIs is a wound infection immediately after implantation of the artificial joint; however, haematogenous infection is also a common source of PJIs. We describe 3 patients, all suffering from (rheumatoid) arthritis, who presented at the emergency department with a wound on the foot or ankle and a swollen and painful prosthetic knee joint, which was functioning well for a long period of time (6 months to 5 years). All patients had several debridements of their infected total knee arthroplasty with local and systemic antibiotics. Patient outcome was widely diverse: from death to successful treatment. These case descriptions are good examples of the different outcomes from a major complication after a small wound. Care should be taken particularly for wounds around the foot and ankle in patients with a total joint arthroplasty, especially those who also have diabetes, rheumatoid arthritis or are immunocompromised.
Insights
Prosthetic joint infections (PJIs) can arise from distant wounds, even years after total joint arthroplasty. Prompt medical care is crucial, as outcomes for these complex infections vary significantly.
Area of Science:
- Orthopedics
- Infectious Diseases
- Rheumatology
Background:
- Prosthetic joint infection (PJI) is a significant complication following total joint arthroplasty.
- While immediate post-operative wound infections are common, hematogenous spread from distant infection sites is also a notable cause of PJIs.
Observation:
- Three patients with rheumatoid arthritis presented with foot/ankle wounds and infected prosthetic knee joints, functioning well for 6 months to 5 years.
- These cases involved multiple debridements and antibiotic treatments, demonstrating diverse clinical presentations and outcomes.
Findings:
- Outcomes for prosthetic joint infections originating from distant wounds, particularly foot and ankle, are highly variable.
- Successful treatment often requires aggressive surgical intervention and antimicrobial therapy.
Implications:
- Healthcare providers should be vigilant for prosthetic joint infections in patients with distant wounds, especially those with underlying conditions like rheumatoid arthritis, diabetes, or compromised immunity.
- Early recognition and management of foot and ankle wounds in patients with total joint arthroplasty are critical to prevent severe complications.
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