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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...

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Related Experiment Video

Updated: May 13, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

[Allergy testing in atopic dermatitis: often unnecessary].

Judith L Thijs1, Roger A M J Damoiseaux, Peter Lucassen

  • 1Afd. Dermatologie en Allergologie, Universitair Medisch Centrum Utrecht, Utrecht, the Netherlands.

Nederlands Tijdschrift Voor Geneeskunde
|March 22, 2013
PubMed
Summary

Allergy testing for atopic dermatitis (AD) is often unnecessary. For children and adults with AD, allergy testing typically does not alter treatment or disease outcomes unless specific allergic symptoms are present.

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Basophil Activation Test for Allergy Diagnosis
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Published on: April 21, 2019

Area of Science:

  • Dermatology
  • Allergology
  • Clinical Medicine

Context:

  • Atopic dermatitis (AD) is a prevalent chronic inflammatory skin condition affecting both children and adults.
  • Primary healthcare settings manage the majority of AD patients in the Netherlands.
  • Current practices lack a definitive consensus on the necessity of allergy testing for AD patients.

Purpose:

  • To evaluate the utility and impact of allergy testing in the management of atopic dermatitis.
  • To determine if sensitization to inhalant or food allergens influences treatment strategies or disease course in AD patients.

Summary:

  • Allergy testing for inhalant allergens in children with AD does not affect treatment or prognosis and is generally not recommended.
  • Testing for food allergens in children with AD is not useful unless acute allergic reactions to food are suspected, to avoid unnecessary elimination diets.
  • For adults with AD, allergy testing for inhalant and food allergens has no impact on treatment unless a clear history of acute allergic reactions exists.

Impact:

  • This evidence suggests that routine allergy testing in AD patients without specific indications may lead to unnecessary interventions and costs.
  • Clarifying the role of allergy testing can help optimize patient management and resource allocation in primary healthcare for AD.