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Updated: May 13, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Clinical "case series": a concept analysis.

F M Abu-Zidan¹, A K Abbas, A F Hefny

¹Trauma Research Group, Faculty of Medicine and Health Sciences, UAE University, Al-Ain, UAE. fabuzidan@uaeu.ac.ae

African Health Sciences

|March 22, 2013

Summary

This summary is machine-generated.

The definition of "case series" in medical literature is unclear. A case series should include more than four patients; fewer should be reported as individual case reports for better research design clarity.

Keywords:

Case report case series concept analysis research design

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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Cloud-Based Phrase Mining and Analysis of User-Defined Phrase-Category Association in Biomedical Publications

Cloud-Based Phrase Mining and Analysis of User-Defined Phrase-Category Association in Biomedical Publications

Published on: February 23, 2019

Area of Science:

Medical research methodology
Clinical study design

Background:

The distinction between case reports and case series in medical literature lacks clear definition.
This ambiguity can impact the interpretation and classification of clinical studies.

Purpose of the Study:

To analyze the concept and definition of "case series" in medical literature.
To compare the characteristics of articles titled "case series" with those designated as "case reports".

Main Methods:

A comprehensive PubMed search was conducted for articles published in 2009 with "case series" in the title.
A total of 586 articles were analyzed for the number of cases and study category.
Excluded articles included commentary letters, non-English papers, and unretrievable publications.

Main Results:

Articles titled "case series" had a median of 7 cases (range 1-6432), with 31.7% having fewer than 5 cases.
Articles classified as "case reports" had a median of 4 cases (range 1-178).
Over half (52.1%) of "case reports" included fewer than five cases.

Conclusions:

The concept of "case series" is not well-defined in current medical literature.
A clear distinction is needed: "case series" should involve more than four patients.
Four or fewer patients should be reported as individual "case reports" to enhance research design specificity.