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Basic helix-loop-helix transcriptional factor MyoR regulates BMP-7 in acute kidney injury

Nozomu Kamiura1, Junichi Hirahashi, Yumi Matsuzaki

  • 1Department of Advanced Nephrology and Regenerative Medicine, University of Tokyo, Tokyo, Japan.

American Journal of Physiology. Renal Physiology
|March 22, 2013
PubMed

Insights

MyoR plays a protective role in adult kidneys. Loss of MyoR exacerbates cisplatin-induced kidney injury by impairing bone morphogenic protein-7 (BMP-7) expression and increasing apoptosis.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Toxicology

Background:

  • MyoR, a transcriptional repressor, has an unclear function in adult kidneys.
  • Understanding MyoR's role is crucial for kidney protection.

Purpose of the Study:

  • To elucidate the functional role of MyoR in adult kidney injury.
  • To investigate the mechanism underlying MyoR's protective effects against cisplatin-induced nephrotoxicity.

Main Methods:

  • Utilized MyoR knockout (MyoR(-/-)) and wild-type mice.
  • Administered cisplatin to induce kidney injury.
  • Analyzed renal dysfunction, tubular injury, mortality, apoptosis, p53 signaling, and BMP-7 expression.
  • Utilized cultured renal proximal tubular epithelial cells (RTECs).

Main Results:

  • MyoR(-/-) mice exhibited increased susceptibility to cisplatin-induced renal dysfunction, tubular injury, and mortality.
  • Cisplatin treatment led to significantly higher apoptosis in MyoR(-/-) kidneys.
  • MyoR deficiency impaired the cisplatin-induced increase in bone morphogenic protein-7 (BMP-7) expression.
  • BMP-7 administration rescued cisplatin-induced apoptosis in MyoR(-/-) RTECs.

Conclusions:

  • MyoR plays a novel protective role in adult kidneys against cisplatin-induced injury.
  • MyoR's protective mechanism involves the regulation of BMP-7 expression.
  • Targeting MyoR or BMP-7 may offer therapeutic strategies for nephroprotection.
Keywords:
AKIBMP-7stem cell

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