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Updated: May 13, 2026
05:10
Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Patient-reported outcomes in the practice-based opportunities for weight reduction (POWER) trial
Summary
The in-person weight-loss program improved physical function quality of life more than the control group. Weight loss significantly boosted overall health-related quality of life, except for sleep quality.
Area of Science:
- Health Services Research
- Behavioral Medicine
- Obesity Research
Background:
- Obesity is a significant public health concern linked to numerous chronic diseases.
- Weight-loss interventions aim to improve health outcomes and quality of life.
- Understanding the impact of different intervention modalities on health-related quality of life (HRQOL) is crucial.
Purpose of the Study:
- To compare the effects of in-person and remote behavioral weight-loss interventions on HRQOL.
- To assess HRQOL changes in obese adults with cardiovascular risk factors.
- To evaluate HRQOL outcomes against a control intervention.
Main Methods:
- 451 obese US adults with cardiovascular risk factors were randomized.
- Participants completed validated measures of HRQOL, depression, and sleep quality at baseline, 6, and 24 months.
- Mixed-effects models analyzed changes in outcomes, controlling for demographic characteristics.
Main Results:
- The in-person intervention group showed significantly greater improvement in physical component summary (PCS) scores over 24 months compared to the control group (P < 0.05, ES = 0.21).
- No other statistically significant differences in HRQOL changes were observed between the active intervention arms and the control arm.
- Greater weight loss was consistently associated with improvements in most HRQOL and depression outcomes (P < 0.05 to < 0.0001).
Conclusions:
- The in-person behavioral weight-loss intervention demonstrated a significant benefit for physical function HRQOL compared to the control.
- Weight loss emerged as a critical determinant for improving overall health-related quality of life, with the exception of sleep quality.
- These findings highlight the importance of weight management in enhancing the well-being of individuals with obesity and cardiovascular risk factors.
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