Related Experiment Video

Updated: May 13, 2026

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
05:44

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery

Published on: November 14, 2018

Intranasal diamorphine in children with trauma

Hannah Skuse1, Vanessa Lawlor

  • 1Frenchay Hospital Emergency Department, North Bristol NHS Trust. hannah.skuse@nhs.net

Emergency Nurse : the Journal of the RCN Accident and Emergency Nursing Association
|March 23, 2013
PubMed

Insights

Intranasal diamorphine offers effective pain relief for children with trauma. This article reviews its safety and administration guidelines for emergency department nurses.

Area of Science:

  • Emergency Medicine
  • Pediatric Care
  • Pharmacology

Background:

  • Pain management in pediatric trauma is critical.
  • Intranasal diamorphine presents a viable alternative for analgesia.
  • Evidence supporting its use in children needs clear summarization.

Purpose of the Study:

  • To discuss the administration of intranasal diamorphine for pain relief in pediatric trauma.
  • To review existing evidence and recent safety data for intranasal diamorphine.
  • To provide practical guidance for emergency department nurses.

Main Methods:

  • Literature review of intranasal diamorphine efficacy and safety.
  • Discussion of a multicenter safety study.
  • Development of administration and assessment guidelines.

Main Results:

  • Intranasal diamorphine is supported by evidence for pediatric analgesia.
  • A recent multicenter study confirmed the safety of an intranasal diamorphine product.
  • Guidelines are provided for nurses regarding patient suitability and monitoring.

Conclusions:

  • Intranasal diamorphine is a safe and effective option for pediatric trauma analgesia.
  • Clear guidelines enhance nurse confidence and patient care.
  • Further research may solidify its role in emergency settings.

More Related Videos

Intranasal Administration of CNS Therapeutics to Awake Mice07:15

Intranasal Administration of CNS Therapeutics to Awake Mice

Published on: April 8, 2013

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
Drugs in...
Epistaxis01:30

Epistaxis

Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...