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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

[Determinants of vascular wall stiffness in patients with chronic renal disease undergoing hemodialysis]

U V Kharlamova, O E Il'icheva

    Klinicheskaia Meditsina
    |March 23, 2013
    PubMed

    Insights

    Patients with chronic kidney disease on hemodialysis experience reduced arterial flexibility and increased arterial thickness. Factors like age, blood pressure, cholesterol, and mineral levels significantly impact arterial rigidity in these patients.

    Area of Science:

    • Cardiovascular Medicine
    • Nephrology
    • Biomedical Engineering

    Background:

    • Chronic kidney disease (CKD) is associated with cardiovascular complications.
    • Hemodialysis is a common treatment for end-stage renal disease, but its long-term effects on vascular health are a concern.

    Purpose of the Study:

    • To assess arterial wall distensibility and thickness in patients undergoing hemodialysis.
    • To identify factors contributing to arterial rigidity in this population.

    Main Methods:

    • Evaluated 109 patients with chronic renal disease undergoing hemodialysis.
    • Measured arterial distensibility using Peterson's and Young's elastic moduli and distensibility coefficient.
    • Assessed common carotid artery relative thickness and pulse wave velocity.

    Main Results:

    • Patients showed significantly impaired arterial wall distensibility.
    • Common carotid artery thickness and pulse wave velocity were significantly elevated compared to healthy subjects.
    • Age, arterial pressure, cholesterol, homocysteine, nitric oxide metabolites, creatinine, calcium, phosphorus, calcium x phosphorus product, hemodialysis duration, and interdialytic weight gain were independent factors influencing arterial rigidity.

    Conclusions:

    • Hemodialysis patients exhibit significant arterial stiffening.
    • Multiple clinical and biochemical factors contribute to the progression of arterial rigidity in CKD patients on hemodialysis.

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