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Updated: May 13, 2026
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Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
Published on: September 22, 2023
Non-allergic, mastocytosis-associated rhinitis
R Dollner1, E Taraldsrud, K Iversen
1Department of Otorhinolaryngology, Head and Neck Surgery, Division for Surgery and Clinical Neuroscience, Oslo University Hospital-Rikshospitalet, Oslo, Norway. ralph@dollner.com
Summary
Non-allergic rhinitis in systemic mastocytosis (SM) is linked to increased nasal mast cells, not allergies. Elevated nasal tryptase, a marker of mast cell burden, correlates with symptoms like rhinorrhea and sneezing in SM patients.
Area of Science:
- Immunology
- Hematology
- Otorhinolaryngology
Background:
- Systemic mastocytosis (SM) involves mast cell (MC) proliferation, leading to mediator release and diverse symptoms.
- A significant portion of rhinitis in SM patients is non-allergic, presumed due to increased nasal MC burden, but lacking direct evidence.
Purpose of the Study:
- To investigate the correlation between allergy-suggesting nasal complaints in non-allergic SM patients and objective measures of nasal MC burden.
Main Methods:
- Eleven adult SM patients meeting ARIA rhinitis criteria underwent rhinologic evaluation.
- Allergologic work-up included serology, tryptase levels (serum/nasal), skin prick tests, and nasal provocation tests.
Main Results:
- Ten of eleven SM patients with allergic rhinitis symptoms were non-allergic.
- Predominant symptoms (rhinorrhea, sneezing, itching) strongly correlated with nasal tryptase levels, not serum tryptase.
Conclusions:
- Non-allergic nasal complaints in SM correlate with elevated nasal tryptase, indicating local MC burden.
- Elevated nasal tryptase is associated with rhinorrhea, sneezing, and itching, suggesting a non-allergic mastocytosis-associated rhinitis (NAMAR).
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