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Updated: May 13, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Oesophageal involvement in bullous pemphigoid
N Maharshak1, M Sagi, E Santos
1Department of Gastroenterology and Hepatology, Sackler Faculty of Medicine, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel Aviv, Israel.
Bullous pemphigoid (BP), a rare autoimmune blistering disease, can affect the esophagus. This case highlights esophageal involvement presenting as gastrointestinal bleeding in an elderly patient.
Area of Science:
- Autoimmune diseases
- Gastroenterology
- Dermatology
Background:
- Bullous pemphigoid (BP) is an acquired autoimmune blistering disease primarily affecting the elderly.
- Mucosal involvement is an uncommon manifestation of bullous pemphigoid.
- Gastrointestinal bleeding can have various etiologies in the elderly population.
Observation:
- An elderly patient diagnosed with bullous pemphigoid presented with significant gastrointestinal bleeding.
- Diagnostic investigations revealed esophageal involvement consistent with bullous pemphigoid.
Findings:
- This case demonstrates a rare presentation of bullous pemphigoid with esophageal mucosal lesions.
- The gastrointestinal bleeding was attributed to the bullous pemphigoid-induced esophageal involvement.
Implications:
- Healthcare providers should consider bullous pemphigoid in the differential diagnosis of gastrointestinal bleeding in elderly patients.
- Recognition of rare mucosal manifestations of BP is crucial for timely diagnosis and management.
- This case underscores the importance of a multidisciplinary approach in managing complex autoimmune conditions.
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