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Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience, such as differences...
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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...

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Updated: May 13, 2026

Combining Intravital Fluorescent Microscopy (IVFM) with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
11:06

Combining Intravital Fluorescent Microscopy (IVFM) with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

PEDF & stem cells: niche vs. nurture.

Philip Fitchev, Chuhan Chung, Beth A Plunkett

  • 1NorthShore Univ. Research Institute, Affiliate of University of Chicago, 1001 University Place, 3rd Floor, Evanston, IL 60201, USA. scrawford@northwestern.edu.

Current Drug Delivery
|March 23, 2013
PubMed
Summary
This summary is machine-generated.

Pigment epithelium-derived factor (PEDF) promotes neural stem cell renewal by upregulating Notch signaling. Enhancing PEDF expression in stem cells shows therapeutic potential for diseases involving angiogenesis and cancer.

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Isolation, Expansion, and Nucleofection of Neural Stem Cells from Adult Murine Subventricular Zone
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Isolation, Expansion, and Nucleofection of Neural Stem Cells from Adult Murine Subventricular Zone

Published on: June 14, 2024

Area of Science:

  • Biochemistry
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Stem cell niche characteristics influence renewal.
  • Pigment epithelium-derived factor (PEDF) is a key factor in stem cell renewal.
  • PEDF regulates neural stem cell (NSC) self-renewal and stemness via Notch signaling.

Purpose of the Study:

  • To investigate the role of PEDF in the neural stem cell niche.
  • To explore the therapeutic potential of enhancing PEDF expression in stem cells.

Main Methods:

  • Investigated PEDF's role in the NSC niche.
  • Examined PEDF and VEGF effects on stem cell differentiation.
  • Assessed therapeutic implications of PEDF-overexpressing stem cells.

Main Results:

  • PEDF upregulates Notch signaling effectors Hes1 and Hes5 in NSCs.
  • PEDF promotes stem cell renewal; VEGF promotes differentiation.
  • PEDF-overexpressing mesenchymal stem cells inhibited angiogenesis and tumor growth.

Conclusions:

  • PEDF is crucial for NSC self-renewal and stemness.
  • Modulating PEDF offers therapeutic strategies for diseases.
  • PEDF is a promising component for novel stem cell-based therapies.