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Ghrelin and glucagon-like peptide-2 increase immediately following massive small bowel resection

Mitsuru Muto1, Tatsuru Kaji, Motoi Mukai

  • 1Department of Pediatric Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 8908520, Japan.

Peptides
|March 23, 2013
PubMed

Insights

New research on short bowel syndrome (SBS) reveals key hormone changes after intestinal resection. Understanding acyl ghrelin, des-acyl ghrelin, and glucagon-like peptide-2 (GLP-2) secretion offers insights for novel SBS therapies.

Area of Science:

  • Gastroenterology
  • Endocrinology
  • Regenerative Medicine

Background:

  • Short bowel syndrome (SBS) presents severe complications in children, necessitating effective treatments for remnant intestinal adaptation.
  • Intestinal adaptation is dependent on feeding and influenced by hormonal signaling.
  • Key hormones like acyl ghrelin, des-acyl ghrelin, and glucagon-like peptide-2 (GLP-2) possess orexigenic and trophic properties.

Purpose of the Study:

  • To investigate the secretion patterns of acyl ghrelin, des-acyl ghrelin, and GLP-2 following massive small bowel resection (SBR).
  • To gather foundational data for developing innovative therapeutic strategies for SBS.
  • To correlate hormonal changes with physiological and morphological adaptations in the remnant intestine.

Main Methods:

  • Utilized 63 growing male rats, divided into control, 80% small bowel resection (80% SBR), and transection/re-anastomosis groups.
  • Monitored body weight, food intake, and remnant intestine morphology for 15 days post-operation.
  • Quantified preprandial acyl ghrelin and des-acyl ghrelin, and postprandial GLP-2 levels.

Main Results:

  • Both acyl ghrelin and des-acyl ghrelin levels increased post-operation in both surgical groups.
  • In 80% SBR rats, des-acyl ghrelin peaked on day 1, while acyl ghrelin and GLP-2 peaked on day 4.
  • Significant GLP-2 secretion was observed in the 80% SBR group (P=2.25×10(-6)).
  • Body weight and food intake in 80% SBR rats returned to preoperative levels by day 4, with morphological adaptations evident thereafter.

Conclusions:

  • Massive small bowel resection triggers distinct temporal secretion patterns for acyl ghrelin, des-acyl ghrelin, and GLP-2.
  • These hormonal changes correlate with functional recovery and morphological adaptation of the remnant intestine.
  • Targeting and reinforcing these physiological hormone secretion patterns may represent a promising therapeutic avenue for short bowel syndrome.

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