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Related Experiment Videos

Topically induced diphenhydramine toxicity.

J F Reilly1, M E Weisse

  • 1Department of Emergency Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas.

The Journal of Emergency Medicine
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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A child experienced acute anticholinergic toxicity from a topical calamine-antihistamine lotion, a rare diphenhydramine toxicity mechanism. Fever from varicella complicated the diagnosis and management of this adverse drug event.

Area of Science:

  • Pediatric Toxicology
  • Dermatology
  • Pharmacology

Background:

  • Topical antihistamine lotions containing diphenhydramine can cause anticholinergic toxicity.
  • Acute anticholinergic toxicity is an uncommon adverse drug event, particularly in pediatric cases.

Observation:

  • A 2 1/2-year-old child presented with symptoms of acute anticholinergic toxicity following the application of a topical calamine-antihistamine lotion.
  • The child also had an underlying varicella infection with fever, which complicated the clinical presentation and diagnosis.

Findings:

  • The case highlights diphenhydramine toxicity as an uncommon mechanism of anticholinergic poisoning.
  • Characteristic signs and symptoms of anticholinergic toxicity were observed, alongside considerations for varicella complications.

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Implications:

  • This case underscores the importance of recognizing rare adverse drug reactions in pediatric patients.
  • Awareness of potential anticholinergic toxicity from over-the-counter topical medications is crucial for clinicians.
  • Proper case management involves differentiating anticholinergic effects from infectious symptoms like fever.