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Relationships between brain metabolism decrease in normal aging and changes in structural and functional

Gaël Chételat1, Brigitte Landeau, Eric Salmon

  • 1INSERM, U1077, Caen, France. chetelat@cyceron.fr

Neuroimage
|March 23, 2013
PubMed
Summary
This summary is machine-generated.

Brain glucose metabolism decline in older adults is linked to white matter (WM) structural changes, particularly in the left inferior frontal junction (LIFJ). This study found no association with functional connectivity, suggesting structural integrity is key in aging brains.

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Published on: February 14, 2014

Area of Science:

  • Neuroscience
  • Gerontology
  • Medical Imaging

Background:

  • Normal aging is associated with reduced brain glucose metabolism, primarily in the prefrontal cortex.
  • The relationship between this metabolic decline and white matter (WM) integrity or functional connectivity in aging is not fully understood.

Purpose of the Study:

  • To investigate the association between age-related decline in brain glucose metabolism and alterations in white matter structural integrity and functional connectivity.
  • To identify specific brain regions and white matter tracts affected by these age-related changes.

Main Methods:

  • Utilized FDG-PET data to measure brain glucose metabolism in young and elderly healthy participants.
  • Acquired T1-weighted MRI for WM volume, diffusion-tensor imaging for fractional anisotropy, and resting-state fMRI for functional connectivity.
  • Performed group comparisons and correlation analyses between metabolism in the left inferior frontal junction (LIFJ) and other neuroimaging modalities in the elderly.

Main Results:

  • Elderly participants showed predominant metabolism decline in the left inferior frontal junction (LIFJ).
  • LIFJ hypometabolism significantly correlated with macrostructural and microstructural white matter disturbances in fronto-temporo-occipital fibers.
  • No significant relationship was found between LIFJ hypometabolism and functional connectivity.

Conclusions:

  • Age-related decline in brain glucose metabolism, specifically in the LIFJ, is associated with white matter structural integrity changes.
  • These findings suggest that white matter microstructural disturbances may play a role in age-related metabolic changes in the brain.
  • Future research should explore the causal relationship between metabolism and connectivity changes in normal aging.