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Updated: May 13, 2026
Measurement of Chitinase Activity in Biological Samples
Published on: August 22, 2019
Can chitotriosidase be a surrogate marker for invasive fungal disease?
1Gulhane Military Medical Academy Training Hospital, Department of Infectious Diseases and Clinical Microbiology, Ankara, Turkey. coskunomer23@hotmail.com
Background:
Chitotriosidase (CHT) enzyme has been known to be secreted from the activated macrophages. We infer with these data that CHT activity is an indicator for the defence.
Methods:
In this study, we evaluated CHT levels in both neutropenic and non neutropenic patients. CHT enzyme activity was measured and compared to each other groups.
Results:
Chitotriosidase levels were found to be significantly higher in neutropenic patients with candidemia.
Conclusion:
In the comparison between neutropenic and non neutropenic patients, there was a significant difference for CHT levels. The use of this enzyme as a surrogate marker for candidemias were evaluated in neutropenic and non neutropenic patients.
