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Elevated endogenous nitrate synthesis associated with giardiasis.

K Wettig1, H J Dobberkau, F Flentje

  • 1Forschungsinstitut für Hygiene und Mikrobiologie Bad Elster, GDR.

Journal of Hygiene, Epidemiology, Microbiology, and Immunology
|January 1, 1990
PubMed
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Patients with giardiasis exhibit significantly elevated urinary nitrate levels, fourfold higher than normal. This increase, potentially from endogenous synthesis, underscores nitrate

Area of Science:

  • Medical Microbiology
  • Clinical Chemistry

Background:

  • Giardiasis is a common intestinal infection.
  • Nitrate metabolism and its clinical implications are not fully understood.

Purpose of the Study:

  • To investigate urinary nitrate levels in patients with giardiasis.
  • To assess the impact of metronidazole treatment on nitrate levels.

Main Methods:

  • Urine samples were collected from 117 giardiasis patients.
  • Nitrate concentrations were measured and compared to normal values.

Main Results:

  • Mean urinary nitrate levels were 155.3 mg/l, approximately fourfold higher than normal.
  • Maximum concentrations reached 1000 mg/l.
  • Metronidazole treatment initially increased, then normalized nitrate levels.

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Conclusions:

  • Endogenously synthesized nitrate in giardiasis patients significantly contributes to their total nitrate load.
  • Urinary nitrate levels can serve as a potential biomarker in giardiasis.