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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

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Related Experiment Video

Updated: May 13, 2026

mirMachine: A One-Stop Shop for Plant miRNA Annotation
06:16

mirMachine: A One-Stop Shop for Plant miRNA Annotation

Published on: May 1, 2021

Online resources for miRNA analysis.

Ioannis S Vlachos1, Artemis G Hatzigeorgiou

  • 1DIANA-Lab, Institute of Molecular Oncology, Biomedical Sciences Research Center Alexander Fleming, 16672 Vari, Greece.

Clinical Biochemistry
|March 23, 2013
PubMed
Summary
This summary is machine-generated.

This review introduces computational tools for microRNA (miRNA) research, covering databases, target prediction, functional investigation, and high-throughput analysis. These web-based resources aid both basic and applied research in mammals.

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Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression with critical roles in various biological processes and diseases.
  • The rapid advancement of miRNA research necessitates efficient computational tools for data analysis and interpretation.

Purpose of the Study:

  • To provide a comprehensive overview of available web-based computational tools and algorithms for microRNA research.
  • To highlight widely used and promising applications for analyzing miRNA sequences, expression, targets, and functions.

Main Methods:

  • Systematic review of web-accessible tools and algorithms for microRNA research.
  • Inclusion criteria focused on user-friendly web interfaces, excluding local installations.
  • Evaluation prioritized tools relevant to Homo sapiens, mice, and rats.

Main Results:

  • Categorization of tools into databases/repositories, target prediction algorithms, functional investigation tools, and analysis pipelines.
  • Presentation of representative examples and case studies demonstrating tool utility.
  • Overview of resources for miRNA sequence and expression data, target identification, and functional analysis.

Conclusions:

  • Computational tools are indispensable for both basic and applied microRNA research.
  • Web-based resources significantly facilitate the analysis of complex miRNA data.
  • Ongoing challenges in the field require continued development and refinement of computational methods.