Related Experiment Video

Updated: May 13, 2026

Knee Arthrocentesis in Adults
04:41

Knee Arthrocentesis in Adults

Published on: February 25, 2022

Association between chronic kidney disease and blood transfusions for knee and hip arthroplasty surgery

Ian D Augustin1, Tze Yeng Yeoh, Juraj Sprung

  • 1Department of Anesthesiology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

The Journal of Arthroplasty
|March 23, 2013
PubMed

Insights

Patients with chronic kidney disease (CKD) undergoing joint replacement surgery had significantly higher odds of requiring blood transfusions. Optimizing CKD patient health before surgery may reduce transfusion needs.

Area of Science:

  • Nephrology
  • Orthopedic Surgery
  • Transfusion Medicine

Background:

  • Chronic kidney disease (CKD) is a growing public health concern.
  • Joint arthroplasty is a common surgical procedure with potential for significant blood loss.
  • The association between CKD and transfusion requirements in arthroplasty is not fully elucidated.

Purpose of the Study:

  • To investigate the association between advanced chronic kidney disease (CKD) and the need for blood transfusions during hospitalization for joint arthroplasty.
  • To identify risk factors for transfusion in CKD patients undergoing arthroplasty.

Main Methods:

  • Retrospective case-control study matching 90 patients with Stage IV-V CKD undergoing elective total knee or hip arthroplasty with 180 controls.
  • Multivariable logistic regression analysis was used to assess transfusion risk.
  • Preoperative hemoglobin, BMI, cardiovascular disease, and surgical complexity were included as covariates.

Main Results:

  • Patients with CKD had lower preoperative hemoglobin and a higher incidence of cardiovascular disease.
  • CKD was independently associated with increased odds of receiving blood transfusions (Odds Ratio 2.88, 95% CI 1.33-6.23, P=0.007).

Conclusions:

  • Advanced chronic kidney disease is an independent risk factor for blood transfusions in patients undergoing joint arthroplasty.
  • Preoperative optimization strategies for CKD patients should be considered to mitigate transfusion rates and improve surgical outcomes.

More Related Videos

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...