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Related Concept Videos

Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is critical for...
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the cerebellum's...
Long-Term Memory01:18

Long-Term Memory

Long-term memory is a relatively permanent type of memory, capable of storing vast amounts of information over extended periods. Its storage capacity is generally considered unlimited.
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or playing an...

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Related Experiment Video

Updated: May 13, 2026

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
07:17

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Published on: June 23, 2022

CREB and neuronal selection for memory trace.

Jieun Kim1, Jeong-Tae Kwon, Hyung-Su Kim

  • 1Laboratory of Neural Circuit and Behavior, Department of Biological Sciences, KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology Daejeon, Korea.

Frontiers in Neural Circuits
|March 23, 2013
PubMed
Summary
This summary is machine-generated.

The transcription factor CREB (cAMP/Ca(2+)-response element binding protein) level is key in selecting specific neurons for memory encoding. This research offers new insights into neural circuits and memory traces.

Keywords:
CREBdendritic spineexcitabilitymemory traceneural networkneuronal selection

More Related Videos

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
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Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

Related Experiment Videos

Last Updated: May 13, 2026

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
07:17

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Published on: June 23, 2022

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Systems Neuroscience

Background:

  • Understanding memory encoding, storage, and expression in neural networks is incomplete.
  • Selective engagement of neurons for memory encoding remains largely unknown.

Purpose of the Study:

  • To review recent findings on molecular and cellular mechanisms of neuron selection for memory traces.
  • To highlight the role of CREB levels in recruiting neurons for memory formation.

Main Methods:

  • Virus-mediated gene delivery to target specific neurons.
  • Molecular imaging of neuronal activity.
  • Pharmacological perturbation and animal behavior assays.

Main Results:

  • Evidence suggests transcription factor CREB levels are critical for selecting neurons in memory traces.
  • This points to molecular mechanisms governing neural recruitment for memory.

Conclusions:

  • CREB levels are a key factor in determining which neurons are recruited into a memory trace.
  • These findings open new perspectives on memory traces at the neural circuit level.
  • Future research with advanced techniques is needed to address emerging questions.