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UPR Signal Activation by Luminal Sensor Domains

Marta Carrara1, Filippo Prischi, Maruf M U Ali

  • 1Department of Life Sciences, Centre for Structural Biology, Imperial College London, London SW7 2AZ, UK. maruf.ali@imperial.ac.uk.

International Journal of Molecular Sciences
|March 23, 2013
PubMed
Summary

The unfolded protein response (UPR) is a cellular system that senses and responds to misfolded proteins in the endoplasmic reticulum (ER). This review explores how UPR sensor proteins detect unfolded proteins to restore cell balance.

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