Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cryo-electron Microscopy

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...

Clot Retraction and Fibrinolysis

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.

Fibril-associated Collagen

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...

Decreased Body Temperature

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Transesophageal echocardiography to rapidly diagnose cardiac herniation following pneumonectomy.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2026

Same author

Idiopathic pericarditis in 2025: Advances in diagnosis and therapeutic strategies.

Autoimmunity reviews·2026

Same author

Impact of ANCA specificity on risk of cardiovascular events and death in ANCA-associated vasculitis.

RMD open·2026

Same author

Overlapping forms of granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis: Insights from a European multicenter study.

Journal of internal medicine·2025

Same author

French national diagnosis and care protocol (Protocole National De Diagnostic et de Soins; PNDS): Gaucher disease.

Orphanet journal of rare diseases·2025

Same author

Evaluation of the mycophenolate mofetil-rituximab combination in systemic sclerosis: a French retrospective multicenter study (MycRiSSc).

Journal of autoimmunity·2025

Search research articles

Related Experiment Video

Updated: May 13, 2026

Tissue Triage and Freezing for Models of Skeletal Muscle Disease

Tissue Triage and Freezing for Models of Skeletal Muscle Disease

Published on: July 15, 2014

Cryofibrinogenemia.

Martin Michaud¹, Jacques Pourrat

¹Departments of Internal Medicine, CHU Toulouse, France. martin.michaud85@gmail.com

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases

|March 23, 2013

Summary

Cryofibrinogenemia is a rare cryoprotein disorder that can cause skin issues and thrombotic events. Early diagnosis and treatment, including avoiding cold and medications, can manage symptoms and prevent complications.

Area of Science:

Hematology
Vascular Medicine
Rheumatology

Background:

Cryofibrinogenemia is a rare cryoprotein disorder characterized by fibrinogen precipitation in plasma.
It can be asymptomatic or present with diverse clinical manifestations, including skin lesions and thrombotic events.
While less studied than cryoglobulinemia, it requires careful diagnosis and management.

Purpose of the Study:

To review the clinical, biological, and pathological features of cryofibrinogenemia.
To discuss diagnostic criteria and management strategies for this rare disorder.
To highlight the importance of considering cryofibrinogenemia in patients with suggestive symptoms.

Main Methods:

Literature review of cryofibrinogenemia, focusing on clinical presentations, diagnostic findings, and treatment options.

More Related Videos

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Published on: November 30, 2015

Related Experiment Videos

Last Updated: May 13, 2026

Tissue Triage and Freezing for Models of Skeletal Muscle Disease

Tissue Triage and Freezing for Models of Skeletal Muscle Disease

Published on: July 15, 2014

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Published on: November 30, 2015

Analysis of histological features and diagnostic criteria.

Comparison with related cryoprotein disorders.

Main Results:

Cryofibrinogenemia presents with skin manifestations (cold intolerance, Raynaud phenomenon, purpura) and systemic thrombotic events.
Histological findings include cryofibrinogen in small/medium arteries and occlusive thrombi.
The disorder can be primary or secondary to other conditions like infections or autoimmune diseases.

Conclusions:

Cryofibrinogenemia is a treatable and potentially reversible condition, with management tailored to disease severity.
Treatment involves avoiding cold, corticosteroids, aspirin, and for severe cases, immunosuppressants or plasmapheresis.
Regular follow-up is crucial due to recurrence risk and potential association with lymphomas.