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Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

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Updated: May 13, 2026

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots
08:30

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Published on: June 2, 2015

Vitamin D and obesity.

Simon Vanlint1

  • 1Discipline of General Practice, School of Population Health, University of Adelaide, Adelaide, South Australia, SA 5005, Australia. simon.vanlint@adelaide.edu.au

Nutrients
|March 23, 2013
PubMed
Summary

Obesity is linked to low vitamin D levels. Further research is needed to confirm if vitamin D supplements can help prevent or treat obesity.

Area of Science:

  • Endocrinology
  • Nutritional Science
  • Public Health

Background:

  • Obesity is a global health issue, especially in developed countries.
  • Vitamin D deficiency is widespread and linked to various health conditions.
  • A consistent association between obesity and reduced vitamin D levels is frequently observed.

Purpose of the Study:

  • To investigate the relationship between obesity and low vitamin D concentrations.
  • To explore potential underlying mechanisms for this association.
  • To examine vitamin D's potential role in obesity prevention and treatment.

Main Methods:

  • Review of existing literature on obesity and vitamin D.
  • Analysis of potential biological mechanisms linking obesity and vitamin D.

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  • Discussion of the need for future research, including prospective intervention studies.
  • Main Results:

    • A consistent correlation is reported between obesity and lower vitamin D levels.
    • Underlying mechanisms require further elucidation.
    • The efficacy of vitamin D supplementation for obesity management is currently uncertain.

    Conclusions:

    • The link between obesity and vitamin D deficiency is well-documented.
    • Prospective, well-powered intervention studies with adequate vitamin D dosing are necessary.
    • The role of vitamin D in obesity prevention and treatment remains to be definitively established.