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Published on: January 12, 2018
Disparities in mortality rates among US infants born late preterm or early term, 2003-2005
Jennifer P King1,2, Julie A Gazmararian3, Carrie K Shapiro-Mendoza4
1Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Rd. NE, CNR Room 3019, Atlanta, GA, 30322, USA. king.jennifer@marshfieldclinic.org.
Insights
Infant mortality rates are higher for late preterm and early term births, especially among minority racial/ethnic groups and younger mothers. Key causes include congenital malformations and sudden infant death syndrome.
Area of Science:
- Perinatal epidemiology
- Public health
- Neonatal outcomes
Background:
- Late preterm (34-36 weeks) and early term (37-38 weeks) births represent a significant proportion of deliveries.
- These infants are at increased risk for adverse outcomes compared to full-term infants.
- Disparities in infant mortality within these gestational age groups are not well-characterized.
Purpose of the Study:
- To identify disparities in neonatal, post-neonatal, and overall infant mortality rates.
- To examine these disparities by race/ethnicity, maternal age, and plurality.
- To determine the leading causes of death in infants born late preterm and early term.
Main Methods:
- Analysis of US period linked birth/infant death datasets (2003-2005).
- Comparison of infant mortality rates stratified by race/ethnicity, maternal age, and plurality.
- Identification of leading causes of death.
Main Results:
- Infants born late preterm to American Indian/Alaskan Native, non-Hispanic Black, or teenage mothers had the highest mortality rates.
- Infants born early term to American Indian/Alaskan Native, non-Hispanic Black, or teenage mothers also showed elevated mortality rates.
- Singletons born late preterm had higher mortality than twins; twins born early term had higher mortality than singletons.
- Congenital malformations and sudden infant death syndrome were leading causes of death for both groups.
Conclusions:
- Significant disparities in infant mortality exist among late preterm and early term infants based on race/ethnicity, maternal age, and plurality.
- Targeted clinical practices and prevention strategies are needed to address the high-risk infants identified.
- Further research into the specific causes and contributing factors for these disparities is warranted.
Abstract:
The purpose of this study was to identify disparities in neonatal, post-neonatal, and overall infant mortality rates among infants born late preterm (34-36 weeks gestation) and early term (37-38 weeks gestation) by race/ethnicity, maternal age, and plurality. In analyses of 2003-2005 data from US period linked birth/infant death datasets, we compared infant mortality rates by race/ethnicity, maternal age, and plurality among infants born late preterm or early term and also determined the leading causes of death among these infants. Among infants born late preterm, infants born to American Indian/Alaskan Native, non-Hispanic black, or teenage mothers had the highest infant mortality rates per 1,000 live births (14.85, 9.90, and 11.88 respectively). Among infants born early term, corresponding mortality rates were 5.69, 4.49, and 4.82, respectively. Among infants born late preterm, singletons had a higher infant mortality rate than twins (8.59 vs. 5.62), whereas among infants born early term, the rate was higher among twins (3.67 vs. 3.15). Congenital malformations and sudden infant death syndrome were the leading causes of death among both late preterm and early term infants. Infant mortality rates among infants born late preterm or early term varied substantially by maternal race/ethnicity, maternal age, and plurality. Information about these disparities may help in the development of clinical practice and prevention strategies targeting infants at highest risk.
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