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Vascular dementia. A clinicopathological study
T del Ser1, F Bermejo, A Portera
1Section of Neurology, Hospital Severo Ochoa, Leganés, Madrid, Spain.
Journal of the Neurological Sciences
|April 1, 1990
Summary
Vascular lesions, including cerebral infarcts and white matter lesions, significantly contribute to dementia in aged patients. These findings highlight the impact of cerebrovascular disease on cognitive decline.
Area of Science:
- Neurology
- Pathology
- Geriatrics
Background:
- Cerebrovascular disease is a common cause of cognitive impairment in the elderly.
- Understanding the specific pathological correlates of dementia in patients with vascular lesions is crucial.
Purpose of the Study:
- To investigate the relationship between various types of cerebral vascular lesions and dementia in aged patients.
- To determine the relative contribution of different vascular pathologies to the dementia syndrome.
Main Methods:
- Retrospective review of clinical and pathological records of 40 aged patients with vascular lesions.
- Comparison of demographic, clinical, and pathological data between demented and non-demented groups.
- Multivariate analysis to assess the influence of specific lesion types on mental deterioration.
Main Results:
- Demented patients showed a significantly higher number of strokes, neurological and neuropsychological disturbances.
- Greater volume of macroscopic cerebral infarct, lacunar state, and white matter lesions were observed in demented individuals.
- Multivariate analysis indicated similar contributions of infarct volume, white matter lesions, and lacunar state to mental deterioration.
Conclusions:
- Cerebral infarct volume, white matter lesions, and lacunar state are significant contributors to dementia in aged patients with vascular pathologies.
- These vascular lesions play a comparable role in the development of the dementia syndrome.