Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Formation of Intermediate Filaments

Formation of Intermediate Filaments

Intermediate filaments are cytoskeletal proteins with higher tensile strength and flexibility than microfilaments and microtubules. Unlike the other two cytoskeletal proteins, intermediate filament formation lacks the enzymatic activity to hydrolyze nucleotides like ATP and GTP to generate energy for polymerization. Therefore, the formation of intermediate filaments is multistep self-assembly. The involvement of any accessory proteins in intermediate filament formation has not yet been reported.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Exploring the neuroprotective mechanism of lumbrokinase against ischemic stroke based on network pharmacology, molecular docking and experimental validation.

Journal of ethnopharmacology·2026

Same author

Integrating Divergence-Based Proteomic Analysis and Directed Network Diffusion to Characterize Diagnosis-Anchored Molecular Variability at the Metabolic Syndrome-Migraine Interface.

International journal of molecular sciences·2026

Same author

Evaluation of randomized controlled trial literature in traditional Chinese medicine: a literature quality assessment system.

Trials·2026

Same author

Evaluating Large-Scale and Lightweight Large Language Models for Traditional Chinese Medicine Exam Questions: A Comparative Study.

Journal of evidence-based medicine·2026

Same author

What Substitution and Prediction Strategies Address the Challenge of an Unmeasurable C2-7 Cobb Angle?

Clinical orthopaedics and related research·2026

Same author

The mediating and moderating roles of physical sub-health in the relationship between family functioning and mental health problems among Chinese adolescents.

BMC public health·2026

Search research articles

Related Experiment Video

Updated: May 13, 2026

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

DNA gridiron nanostructures based on four-arm junctions.

Dongran Han¹, Suchetan Pal, Yang Yang

¹The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA. dongran.han@asu.edu

Science (New York, N.Y.)

|March 23, 2013

Summary

Researchers engineered complex DNA nanostructures using a novel design strategy. This method creates versatile DNA gridirons for advanced nanotechnology applications.

More Related Videos

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Related Experiment Videos

Last Updated: May 13, 2026

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Area of Science:

Nanotechnology
Molecular Engineering
Biomolecular Self-Assembly

Background:

Engineering complex nanoscale architectures is a significant challenge in nanotechnology.
DNA nanotechnology offers a promising platform for creating precise molecular structures.

Purpose of the Study:

To present a design strategy for constructing gridiron-like DNA structures.
To explore the assembly of reconfigurable 2D, multilayer, 3D, and curved DNA architectures.

Main Methods:

Utilizing four-arm DNA junctions as vertices in a network of double-helical DNA fragments.
Employing deliberate distortion of DNA junctions to enable scaffold strand traversal in multiple directions.
Assembling DNA gridirons with varying complexity and dimensionality.

Main Results:

Successful assembly of gridiron-like DNA structures.
Demonstration of reconfigurable two-dimensional DNA arrays.
Creation of multilayer, three-dimensional, and curved DNA objects.

Conclusions:

The presented design strategy enables the creation of complex, gridiron-like DNA architectures.
This approach offers versatility for building diverse nanoscale scaffolds.
The DNA gridiron structures have potential applications in advanced nanotechnology.