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Updated: May 13, 2026

A Protocol for Functional Assessment of Whole-Protein Saturation Mutagenesis Libraries Utilizing High-Throughput Sequencing
Published on: July 3, 2016
Pathogen mutation modeled by competition between site and bond percolation
Laurent Hébert-Dufresne1, Oscar Patterson-Lomba, Georg M Goerg
1Département de Physique, de Génie Physique, et d'Optique, Université Laval, Québec, Québec, Canada G1V 0A6.
Abstract:
While disease propagation is a main focus of network science, its coevolution with treatment has yet to be studied in this framework. We present a mean-field and stochastic analysis of an epidemic model with antiviral administration and resistance development. We show how this model maps to a coevolutive competition between site and bond percolation featuring hysteresis and both second- and first-order phase transitions. The latter, whose existence on networks is a long-standing question, imply that a microscopic change in infection rate can lead to macroscopic jumps in expected epidemic size.
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